XS-GRAFT

New vascular prosthesis to improve the quality of life of dialysis patients

Terminal renal failure is a growing medical problem and is driving an increased demand for renal replacement therapies. For the majority of patients haemodialysis is used. In this technique the blood is purified using an artificial kidney and requires access to the bloodstream via a connection between a vein and an artery, known as an arteriovenous fistula. In a significant number of cases the arteriovenous fistula fails due to thrombosis or lack of maturation, which requires the use of a vascular prosthesis for vascular access. However, the chances of developing a vascular constriction in these prostheses are high, which can result in thrombosis and blockage. By creating a new type of prosthetic material with optimum mechanical properties and blood compatibility, we will significantly reduce the risk of vascular constrictions, prolonging and improving the function of the implant and benefiting the patient’s quality of life.

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Project status 2016-2017

During the first year, the team identified the user needs for a vascular access graft. Together with physicians, patients as well as engineers and material scientists the user needs were translated into technical requirements that systematically describe the functional, regulatory, and physical user needs of the graft design. The next step will be to confirm these results in a large animal model that better represents the AVG placement in the human situation. Future studies will further investigate the effect of graft morphology and flow dynamics on blood compatibility and tissue growth to optimize the design of the graft.

Patricia Dankers

Project Leader

Patricia Dankers, PhD
Eindhoven University of Technology                        

Project partners

Eindhoven University of Technology, Maastricht University and University Medical Center, DSM

Chemelot InSciTe